Patients with hemophilia A or B with inhibitors have actually a lower annualized bleeding rate with concizumab than without any prophylaxis, according to a stage 3 research study released online Aug. 31 in the New England Journal of Medicine
Tadashi Matsushita, M.D., Ph.D., from Nagoya University Hospital in Japan, and associates examined the security and effectiveness of concizumab in clients with hemophilia A or B with inhibitors. As part of the explorer7 stage 3 trial, individuals were arbitrarily appointed to get no prophylaxis for a minimum of 24 weeks (group 1; 19 clients) or to get concizumab prophylaxis for a minimum of 32 weeks (group 2; 33 clients), or they were nonrandomly designated to get concizumab prophylaxis for a minimum of 24 weeks (groups 3 and 4; 81 clients).
The scientists discovered that the approximated mean annualized bleeding rate in group 1 was 11.8 episodes versus 1.7 episodes in group 2 (rate ratio, 0.14; P < < 0.001). For clients getting concizumab (groups 2, 3, and 4), the total typical annualized bleeding rate was no episodes. After concizumab treatment was rebooted, no thromboembolic occasions were reported. Plasma concentrations of concizumab were steady in time.
” Concizumab represents an unique, subcutaneous treatment choice in clients with hemophilia A or B with inhibitors that can possibly enhance long-lasting results,” the authors compose.
More info: Tadashi Matsushita et al, Phase 3 Trial of Concizumab in Hemophilia with Inhibitors, New England Journal of Medicine(2023). DOI: 10.1056/ NEJMoa2216455
H. Marijke van den Berg et al, Hemostasis– A Balancing Act, New England Journal of Medicine(2023). DOI: 10.1056/ NEJMe2304535
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Citation: Concizumab might work prophylaxis for hemophilia A or B with inhibitors (2023, September 3) obtained 3 September 2023 from https://medicalxpress.com/news/2023-09- concizumab-effective-prophylaxis-hemophilia-inhibitors. html
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